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The injectable forms were approved first, with Ozempic receiving FDA approval in 2017 for type 2 diabetes and for reducing major adverse cardiovascular events in adults with type 2 diabetes and established cardiovascular disease

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By binding to GLP-1 receptors in the hypothalamus, they reduce appetite and promote satiety, leading to significant weight reduction in clinical trialswith newer agents achieving approximately 15% weight loss in obesity without diabetes (semaglutide) and up to 21% (tirzepatide), with somewhat lower reductions typically seen in patients with type 2 diabetes

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