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A lower dose of insulin or insulin secretagogue may be required

Results vary with dosage and treatment duration, with higher doses and longer use leading to more weight loss

Importantly, although several of these interventions have demonstrated benefits in improving liver-related outcomes or reducing postoperative infections, direct evidence supporting their efficacy in preventing postoperative delirium (POD) remains limited

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Then, when you look at the STEP 4 trial, which randomly assigned participants receiving semaglutide 2.4 mg at 1 year to continue the drug or receive placebo, most of the patients who stopped semaglutide regained their weight

While our study showed modest placebo effects, future research should explore population-specific variations and methodological factors that contribute to treatment perception and outcomes