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As GLP-1Rs are expressed in multiple brain regions, and GLP-1RAs such as liraglutide and lixisenatide can penetrate the blood-brain barrier, liraglutide and exendin-4 can be vagus-dependent or independent in the suppression of the food intake (176)

Advancing research into microbiome profiling, combined with genomics and metabolomics, will help identify biomarkers for disease prediction and personalized treatment plans

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