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Consequently, GDH emerges as a promising therapeutic target during tumour growth, proliferation, invasion, and metastasis

In contrast, medications such as cangrelor, a parenteral antiplatelet agent, warfarin, and some cardiac medications, such as statins and angiotensin-converting enzyme inhibitors appear to not be as impacted by decreased gastric motility [17,18]

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Since the development of the first GLP-1 medication, Byetta, by Amylin Pharmaceuticals in 2005 and its commercialization by AstraZeneca, these drugs have been widely used for managing type 2 diabetes

This research is conducted in the context of broader structure-activity work on phenylethanolamine compounds, comparing synephrine's substitution pattern to other adrenergic agonists with different subtype selectivity to map which structural features drive beta-3 preference