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Substances that are absorbed through the buccal route go directly into the systemic circulation and this eliminates disadvantages imposed by oral intake, such as the decreased ability of GSH to pass through the gastrointestinal tract as an intact molecule

Percentages use total AE mentions (N=4,254) as the denominator

J Auton Pharmacol 20:325332

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This advanced delivery mechanism may allow for more efficient utilisation at optimised dosages, supporting consistent performance outcomes and formulation versatility