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They exist in a regulatory limbo: too potent to be sold as dietary products, yet too unregulated to be treated as medicine

Cell Metab 23:591601 Apovian CM, Aronne LJ, Bessesen DH et al (2015) Pharmacological management of obesity: an Endocrine Society clinical practice guideline

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Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism

Factors such as baseline body composition, pre-existing thyroid function, nutritional status, and environmental temperature all influence whether a patient experiences cold sensitivity