Vitamins like A, D, E, and K are fat-soluble and can be hard on the kidneys
Extensive persistent inflammation even when SARS-CoV-2-infected cells are only sporadically present at late stages of COVID-19 (Schurink et al., 2020) could also justify low GSH levels in association with over-abundance of cellular ROS, cellular oxidative damage, increased inflammation and cell death pathways activation seen in inflammaging (Zuo et al., 2019
Kunwar A, Mishra B, Barik A et al (2007) 3,3-Diselenodipropionic acid, an efficient peroxyl radical scavenger and a GPx mimic, protects erythrocytes (RBCs) from AAPH-induced hemolysis
Meanwhile, low levels of follicular glutathione are associated with premature ovarian aging and lower fertilization rates
S.BaughK.JechowA.HlkerF.et al (2017a)
Clinical dosing of NAC has been shown to successfully lower systemic and hepatic inflammatory markers, specifically reducing ALT (alanine aminotransferase), IL-6 (Interleukin 6), and TNF- (Tumor Necrosis Factor-alpha)