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As a result of that, initial recommendations focus on the use of metformin or a thiazolidinedione if metformin is contraindicated, followed by a GLP-1 agonist or a DPP-4 inhibitor

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doi:10.1056/NEJM198209093071104 Chan et al

As your clinician titrates your dose upward (which is medically necessary), the monthly price can increase by 50100%

The larger width of the prediction intervals is due to the noted parameter uncertainty