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Russo et al., 2018)

Other significant considerations include: Injection site reactions (for subcutaneous formulations) Hypoglycaemia risk (particularly if used alongside other glucose-lowering medications) Pancreatitis (rare but serious) Gallbladder disease (including gallstones and cholecystitis) Dehydration leading to acute kidney injury (particularly with severe gastrointestinal side effects) Diabetic retinopathy complications (particularly noted with semaglutide in diabetes patients) Potential thyroid effects (medullary thyroid carcinoma risk in animal studies, though human relevance remains unclear) A Parkinson's-specific concern is that GLP-1 receptor agonists delay gastric emptying, which may further impair levodopa absorption and potentially worsen motor fluctuations or 'OFF' periods in patients on this medication

It is also active in the brain, where the receptors it binds to cluster in regions governing reward, motivation and stress the same circuitry that gets hijacked by addiction

254 (Pt 2), 127955

Fractional gluconeogenesis was determined using 2 H 2 O and the average enrichment of 2 H enrichments of carbon 1,3,4,5,6 of glucose as previously described [21]

Data were collected and stored automatically in a dedicated computer that ran and analyzed the data (Dataquest)