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However, the effects are dose-dependent, and optimal concentrations appear to vary by context, underscoring the need for application-specific protocols

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Simon, L., Zini, A., Dyachenko, A., Ciampi, A

This distinction matters

1,2 Each of these definitions carries a different meaning, and what the half-life of a drug is found to be can also vary or appear to vary depending on contexts such as formulation, route of administration, and individual variations in drug distribution, metabolism, and excretion, among other factors