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The 2019 Global Burden of Disease Study reported that 4.3% of deaths and 3.7% of disability-adjusted life years (DALYs) are attributable to alcohol.1 Alcohol consumption is associated with cancer risk, as stated previously, and the International Agency for Research on Cancer (IARC) has classified alcohol as a Group 1 carcinogen.2 According to a study on the global burden of cancer, alcohol accounted for 5.2% of all cancer DALYs in 2019 (7.4% in males, 2.3% in females).3 Additionally, an estimated 741,300 new cancer cases (95% confidence interval [CI], 558,500951,200) in 2020 were attributable to alcohol consumption.4 Alcohol consumption is a major risk factor for a wide range of cancers, including oral, pharyngeal, laryngeal, esophageal, liver, pancreatic, colorectal, and breast cancers.5 Smoking is also classified as a Group 1 carcinogen by the IARC and is known to be a major risk factor for various cancer.6 Studies have investigated alcohol consumption and cancer risk, considering smoking as a major confounding factor, but alcohol consumption and smoking may interact
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