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Young and old rats exposed to Epithalon had stimulated skin fibroblast proliferation by 29-45%

It further outlines techniques to measure lipid peroxidation (MDA, 4-HNE), protein carbonylation (DNPH method, 3-nitrotyrosine via LCMS), DNA damage (8-OHdG detection by HPLCMS/MS), and inflammation markers (RT-qPCR for cytokines)

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108 KraussM.WeissT.LangnaeseK.RichterK.KowskiA.VehR

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Patutina OA, Gaponova Miroshnichenko SK, Senkova AV et al (2020) Mesyl phosphoramidate backbone modified antisense oligonucleotides targeting miR-21 with enhanced in vivo therapeutic potency