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Breg cells are believed to regulate the induction of autoimmune disease by inhibiting the differentiation of Th1 and Th17 cells, while promoting the proliferation of Treg cells [74]

This is because non-economic damages (e.g., pain and suffering, mental distress, etc.) are difficult to quantify

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2009 Jul;66(7):756-63. PMID: 19581567

NMR Biomed e4257

The duration required to obtain the desired number of events can be estimated from previous CVOTs, and the number of probable events in the placebo and intervention arms can both be estimated while predicting the direction of the effect size (hazard ratio)