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Subcutaneous administration, however, is associated with several usual drawbacks such as injection pain, inconvenience, social distress and/or injection phobia
This review summarises the clinical evidence for GLP-1RAs and how they compare to other glucose-lowering agents in managing type 2 diabetes
0.13% B
N-terminal acetylation, the Nle 4 substitution (methionine replaced by norleucine, oxidation-resistant), the D-Phe 7 substitution (stereochemical inversion resistant to proteolysis) and lactam cyclization are the four pharmacochemical innovations that transform alpha-MSH's 2-5 minute half-life into a multi-hour half-life
In this context, interaction between AX and thiol molecules may stablish an acid-base equilibrium, which generates catalytic amounts of thiolate anion
