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On the other hand, Co triggers DNA methylation in Vicia faba seeds (Rancelis et al., 2012) while Cu is harmful to young sunflower plants, causing oxidative stress by producing ROS and reducing catalase activity (Garca et al., 1999

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The copper in GHK-Cu is chelated (bound to the peptide), which silences coppers redox activity and prevents the oxidative damage associated with free copper ions