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Major health organizations allow the use of aluminum hydroxide in personal care products and have not flagged it as a carcinogenic risk at typical usage levels

While this reaction was traditionally viewed as a minor nicotinamide clearance pathway, research has revealed that NNMT activity has far-reaching consequences for cellular metabolism through multiple interconnected mechanisms

In vitro telomere elongation does not automatically translate to slower aging in living humans

A 2025 narrative review of musculoskeletal research described both the regenerative findings and the open questions about translation to human clinical use (PMID 40789979)

Figure 8 Abnormal coagulation: the role of microclots and inflammagens in circulation that cause pathological clotting It has been hypothesised that hypercoagulation plays a significant role in ME/CFS (349351), but there are still discrepancies between studies (352)