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In 1979, Creutzfeld explained the phenomenon, stating that the digestive tract secretes hormones that amplify the glucose signal to induce insulin secretion [16]

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Within the ARC, two primary, functionally antagonistic neuronal populations serve as first-order neurons: the anorexigenic pro-opiomelanocortin (POMC)-expressing neurons and the orexigenic agouti-related protein (AgRP)/neuropeptide Y (NPY)-expressing neurons [6]

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Engaged participants achieved greater mean weight loss over time and reached clinically significant weight loss thresholds more rapidly than their nonengaged counterparts