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Once activated, ERK1/2 is transferred to the nucleus, where it phosphorylates transcription factors such as c-Myc and c-Fos, leading to the expression of genes responsible for cellular regulations such as cell proliferation, differentiation, and migration

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These studies used an older radioisotope dilution method for measuring milk vitamin B-12 concentrations, the validity of which has been questioned (29), as opposed to our chemiluminescence method, so direct comparisons are difficult to make

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This strategy has been validated in randomized study [122], but most of the studies recommend supplements through the oral route [123,124,125,126,127,128,129]

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