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In some of such instances, for example, a next dose is administered when drug concentration drops below saturation levels of the second receptor and/or the C min The combination of immediate release, delayed release and/or extended release otic compositions or formulations are combined with other pharmaceutical agents, as well as the excipients, diluents, stabilizers, tonicity agents and other components disclosed herein

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10.15386/mpr-1375 71 Nabavi-RadA.SadeghiA.Asadzadeh AghdaeiH.YadegarA.SmithS