In vitro experiments revealed that Fer-1 treatment effectively reversed the LPS-induced alterations in ROS, Fe 2+ , GPX4, and SLC7A11 levels in corneal stromal stem cells (CSSCs)
However, the available studies emphasise that much of the data comes from preclinical models, cellular studies and older publications in the area of experimental gerontology, so interpretation of the results should take into account the experimental nature of this substance and the limited scale of modern, high-quality clinical trials
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doi: 10.1038/s41380-020-00920-2 160 StevensJ