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Bottom line: Increasing your dosing frequency to every 5 days is a high-risk move with little proven reward

A study of high-fat diet-induced obesity in young rats

Sogut S, Zoroglu SS, Ozyurt H, Yilmaz HR, Ozugurlu F, Sivash E, Yetkin O, Yanik M, Tutkun H, Savas HA: Changes in nitric oxide levels and antioxidant enzyme activities may have a role in the pathophysiological mechanisms involved in autism

And that somewhere down the line, in some vague way, it's probably good for your health too

[9] Niacinamide (nicotinamide), a water-soluble amide of vitamin B3, elevates intracellular NAD pools, activates PARP-mediated DNA repair, and decreases pro-inflammatory cytokines such as IL-8 and IL-1

But what actually is berberine