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Acknowledgements The authors thank the Brazilian Coordination for the Improvement of Higher Education Personnel (CAPES), the Brazilian National Council for Scientific and Technological Development (CNPq), the Instituto Tecnolgico Vale and Vale for the financial support in the development of this work and for the scholarships provided

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Physiological alterations, such as abnormal redox and mitochondrial metabolism, are linked to ASD

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Under a non-monotonic curve, an increase producing less effect is ambiguous: it cannot distinguish being below the peak from having passed it