However, for some patients, these side effects can be significant enough to warrant discontinuation of the therapy
Due to the observational study design, an inherent limitation was residual confounding by unmeasured confounders such as household annual income and other socioeconomic status, which might affect choice of diabetes medications and development of AF
Great synergy between NH3 and proinflammatory cytokines, especially TNF, has been described in studies conducted on patients with cirrhosis.59 As mentioned before, lactate also plays an important role in neuro-inflammation
Furthermore, it is unknown if the mechanisms of action would have been observed during full-body dynamic exercise where there is a higher aerobic and metabolic demand, as CM ingestion seems to be more appropriate for this type of exercise ( see proposed ergogenic mechanisms section )
However, in some cases, patients with pre-existing kidney disease or dehydration may need to take precautions
Paoli, Cenci, & Grimaldi, 2011