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However, emerging evidence from PubMed-indexed research shows that in AD models, excessive cGASSTING activation contributes to chronic neuroinflammation in microglia and neurons, exacerbating pathological processes such as amyloid- (A) plaque accumulation, tau pathology, and neuronal injury

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At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta

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