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In the case of manipulations that prevent - arrestin2 binding, it was proposed that - arrestin2 association is necessary for, or facilitates MOR desensitization (Bohn et al., 2002, 2004), but this is not the case

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This extended duration of action results from the peptide's resistance to enzymatic degradation rather than prolonged circulation, allowing for less frequent dosing while maintaining physiological growth hormone patterns

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