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The Indianapolis pharmaceutical company reported sales of Zepbound and Mounjaro at the beginning of 2025 of 1,910 million dollars and 3,530 million dollars respectively, according to Reuters

Extra weight increases mechanical stress on the knee, and "visceral adipose tissue secretes adipocytokines and other soluble mediators that increase pain." Felson added that the trial's findings are similar to those from a 2023 study that examined the effects of GLP-1 receptor agonists on adults who had both type 2 diabetes and knee osteoarthritis

Mechanism of Action GLP-1 medications work by binding to GLP-1 receptors found throughout the body, particularly in the pancreas, brain, and gastrointestinal tract

These medications mimic natural GLP-1, a naturally occurring hormone produced by the body that plays a crucial role in how our bodies regulate blood sugar and appetite

Who is a good candidate for this therapy