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Together with the observation that CNS myelin appears to be a major target, this spurred development of various animal models, with the experimental autoimmune encephalomyelitis (EAE) mouse model being the most popular (Baxter, 2007)
Kania, A
[v] Outsourcing Facilities Assn v
Structural analyses indicate that -amylase activity requires calcium ions to maintain structural integrity and is activated by chloride ions, and similarly, -glucosidase operates via a Koshland double displacement reaction mechanism (64)
When reproducible physiology and biochemistry persist across years, modalities, and care settings, the question stops being is anything wrong? and becomes a governance one: Who owns the trigger for reevaluation when signals persist but dont fit a textbook pathway and where is that ownership documented so cases dont stall between handoffs