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The analysis identified 56 metabolites in urine, 8 in bile, 19 in plasma and 5 in liver microsomes, highlighting both hepatic and extrahepatic biotransformation pathways [21]

Accuracy was expressed as the mean recovery (RE), and precision as the coefficient of variation (CV)

Water retention typically manifests as mild peripheral edema in the hands and feet, peaking in weeks 24 and resolving partially by week 6 as aldosterone regulation adapts

Author contributions Y.S.: study design, study conduct/data collection, writing the manuscript

Stroke 36 (6), 13301340

Dopaminergic afferents from the ventral tegmental area (VTA) in the midbrain project largely to the NAc (mesolimbic pathway), while the substantia nigra (SN) pars compacta is the main source of dopamine in the dorsal striatum (nigrostriatal pathway)