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2017 meta-analysis: A systematic review and meta-analysis of nine randomized controlled trials showed that ALCAR supplementation significantly decreased depressive symptoms compared to placebo (standardized mean difference 1.10, 95% CI 1.65 to 0.56), with effects comparable to established antidepressants like fluoxetine, particularly in older adults or those with treatment-resistant depression [5][30]

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The transcription factor Nrf2 contributes to the regulation of genes involved in glutathione synthesis and other antioxidant-response pathways

This table and figure represent the improvement of the BDI score in each case and control group, over time

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