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This study defines the unique avascular nutrition mechanisms of the IVD

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These regulators can be subject to negative regulation by NAD +, which occurs through a process of direct deacetylation of SIRT1 and SIRT6 (Wu et al

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This leads to decreased calcium levels in the blood (hypocalcemia) by suppressing the secretion of parathyroid hormone and increased renal excretion of calcium (hypercalciuria).

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