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As a target of let-7 family, IGF-1R can promote the cell proliferation through the crosstalk between IRS-2/Akt and MAPK pathways 46,47

Most malignant peripheral nerve sheath tumors arise from the nerve plexuses that distribute nerves into the limbsthe brachial and lumbar plexusesor from nerves as they arise from the trunk

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Conflict of interest The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest

109 (IARC, WHO, 2016)