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Discussion We have created a whole body model of acetaminophen transport and metabolism that includes the details of the biochemical pathways of acetaminophen metabolism in the liver and peripheral tissues

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Adverse effects include blood pressure lowering, peripheral edema and slowing of peristaltic movements in the intestines

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Glutathione S -transferase activities in mock- and GSTP1 -transfected HepG2 cells were in a similar range as reported previously in mock- (and GSTP1 -)transfected HepG2 cells (Peklak-Scott et al., 2008)