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Its large molecular size (~ 63 kDa) reduces renal clearance and prolongs its half-life to approximately 45 days, allowing once-weekly subcutaneous administration

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If a patient were to be put on a GLP-1 for this purpose, how important is it to also educate them about diet and exercise as ways to lose weight and reduce pain

Injection site selection matters, with subcutaneous administration into the abdomen, thigh, or upper arm being the standard approach

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