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Brown or blue pigmented lesions may be caused by overproduction of melanin in basilar melanosis or in benign nevi and malignant melanomas, which are associated with melanocyte overpopulation

This irreversible aggregation induced by phase separation changes RBPs to insoluble fibrils, which may be an important cause of RBP-linked proteinopathies

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10.3389/fendo.2017.00314 110 ManzellaL.MassiminoM.StellaS.TirrE.PennisiM

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