[13] In GPX1 (-/-) mice, oxidant formation is increased, endothelial NO synthase is deregulated, and adhesion of leukocytes to cultured endothelial cells is increased
Therefore, the use of genetically engineered cells with human CYP overexpression or HepaRG cells with stable metabolic competence, low batch-to-batch differences and the potential to form bile canaliculi and functional tight junctions might represent more valuable, practical alternatives for genotoxicity screening of NAs, as recently reported (Carlsson et al
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Oxidative dimerization in metallothionein is a result of intermolecular disulphide bonds between cysteines in the -domain
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