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The defining feature of this metabolic state is chronic energy flux constrictiona persistent reduction in nutrient delivery coupled with maintained or redistributed oxidative demand

doi: 10.1080/17461391.2023.2213185, 38

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Whether they will become a sustainable solution or a short-lived trend remains to be seen

Tirzepatide is administered as a once-weekly subcutaneous injection, with doses typically starting at 2.5 mg for initiation (not for glycemic control)

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