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This debate is reflected in a number of animal models and several human diseases, including careful analysis of human MS (Figure 3
The number of clusters (k=5) was chosen objectively by maximizing a combined score of: Silhouette coefficient on a discovery split: measures how well-separated the clusters are internally Adjusted Rand Index (ARI) on a held-out validation split: measures whether an independent reclustering of new data produces the same structure This two-stage validation approach guards against over-fitting the cluster count to a single sample
Perhaps it is not a coincidence that EBV, the main virus implicated in MS, is also a herpes virus, whose genes code for more than 12 distinct glycoproteins, five of which are essential for infecting B cells (Hutt-Fletcher, 2015)
While results may vary, interest in this application continues to rise
Interaction of leptin and amylin in the longterm maintenance of weight loss in dietinduced obese rats