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Later, the same research team found that keratinocyte-specific knockout mice lacking GPX4 showed aberrant epidermis proliferation, infiltration of inflammatory cells in the dermis, and morphologic alteration of hair follicles
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First, its high plasma protein binding limits brain uptake by reducing the free amount of the drug in the circulation [16]
Importantly, recent evidence has indicated that a significant proportion of the variation in warfarin dose requirements can be attributed to common pharmacogenetic variation among genes involved in warfarin pharmacokinetics and pharmacodynamics, most notably CYP2C9 and VKORC1 , respectively
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