10.1016/j.neulet.2014.09.039 13 BejE.CesareP.dAngeloM.VolpeA
In: Ziegler E, Filer L, eds
Pathogenesis of cigarette smoke-induced chronic obstructive pulmonary disease and therapeutic effects of glucocorticoids and N-acetylcysteine in rats
Il GLP1 prodotto anche da parte delle cellule della glia e, anche in questo contesto, eserciterebbe un ruolo anti-infiammatorio, favorendo la sopravvivenza cellulare e inibendo la fosforilazione delle proteine tau e laccumulo di placche amiloidi [22, 23]
Causes (Why IBS Happens) IBS is usually a mix of factors : Gutbrain communication changes (nerves become extra sensitive) Altered motility (colon moves too fast or too slow) Microbiome shifts after infection, antibiotics, or stress Food triggers (e.g., highFODMAP foods, excess caffeine) Stress, anxiety, or poor sleep (they dont cause IBS but can magnify it) Pathophysiology (In Simple Terms) Think of the gut like a microphone turned up too loud: Visceral hypersensitivity: normal gas/stretch feels painful
When combined with clinical assessment, genetic insights can deepen the candidacy conversation