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B12s role in maintaining healthy circadian rhythms may help prevent the sleep disturbances and daytime fatigue commonly experienced with SAD

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It reduces reactive oxygen species while upregulating antioxidant enzymes like superoxide dismutase, catalase, and glutathione

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Specifically, there was smaller anterior cingulate cortex in the BD SOD2 rs4880 GG group compared to the healthy group with the same SNP, and smaller frontal and parietal lobes in the BD glutathione peroxidase 3 rs3792797 A-allele carrier group compared to the BD CC and HC A-allele carrier groups

The area postrema downregulates amylin receptor density in response to sustained agonism, which is how nausea resolves over time