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CJC-1295 without DAC is a shorter-acting GHRH analog commonly referred to as Modified GRF 1-29

10.1016/j.biopha.2019.01.034 Summary Keywords GLP-1, GLP-1 analog, diabetic retinopathy, mitophagy, retinal ganglion cell Citation Zhou H, Ma X, Lin W, Hao M, Yu X, Li H, Xu C and Kuang H (2021) Neuroprotective Role of GLP-1 Analog for Retinal Ganglion Cells via PINK1/Parkin-Mediated Mitophagy in Diabetic Retinopathy

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This receptor activation initiates a signaling cascade that: Amplifies the amplitude and frequency of natural GH pulses Enhances sleep-related GH secretion Synergizes with Growth Hormone-Releasing Hormone (GHRH) to further elevate GH output The result is a physiologic, pulsatile increase in GH , followed by elevated Insulin-like Growth Factor 1 (IGF-1) , which drives muscle growth, recovery, and repair