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During this phase, typically occuring several years prior to arthritis onset, genetic and environmental risk factors interact, leading to a loss of self-tolerance and the development of autoantibodies, such as rheumatoid factors (RF) and anti-citrullinated protein antibodies (ACPA) (2, 3)

Any smoker who quits will likely experience some weight gain, but why does it happen

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Fidler JA, Jarvis MJ, Mindell J, West R: Nicotine intake in cigarette smokers in England: distribution and demographic correlates