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[27] [28] MC 4 receptor antagonists produce pronounced antidepressant- and anxiolytic-like effects in animal models of depression and anxiety

Serious but rare adverse effects specifically mentioned include pancreatitis, gallbladder disease, acute kidney injury (typically related to dehydration), and hypoglycemia when used with insulin or insulin secretagogues

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Tinnitus is a condition where a person hears persistent ringing, buzzing, hissing, or whooshing in the ears without an external source of sound