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Besides diet-induced inflammation, environmental factors including obesity, viruses, smoking, tobacco use and VitD deficiency, are also considered risk factors for MS, potentially altering the microbiome and causing a leaky gut observed in PwMS and EAE animals (438)
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Opioid use may worsen gastric retention Higher prevalence of recent opioid use in the high RGC group Suggests an additive effect on gastric motility No difference in indication or duration of therapy Whether patients used GLP-1 RAs for diabetes or weight loss did not affect risk Duration of therapy was not a significant predictor Interpretation Withholding 7.5 days higher risk of retained gastric contents Fasting 21.3 hours strongest predictor of high RGC These thresholds optimize sensitivity and specificity for detecting risk
Seferovi, P
Both medications share the same rarer but more serious risks listed for the GLP-1 class, including pancreatitis and gallbladder problems, so any severe or persistent stomach pain should be checked by a doctor
What Affects Your Initial Results Several elements can impact how much weight you lose during the first few months
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