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The LCMS metabolite peaks were manually integrated and identified using El-Maven (v.0.12.0) by matching with a previously established in-house library 33

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In the non-oxidative reactions 2 NADPH are produced in the conversion of glucose 6-phosphate to ribulose 5-phosphate

SIRT-1 , Sirtuin-1

A recent study showed that glucose metabolism was dysregulated and that pyruvate supplementation could prevent neurodegeneration in an animal model of glaucoma 31 , suggesting that ATP production from glycolysis is disrupted, and that other energy fuel pathways, such as -oxidation, may be augmented to compensate for the reduction in energy metabolism

Performance edge: Improves nutrient uptake and protein synthesis, supporting faster adaptation to training