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127 It is also observed that suppressing the expression of PKM2 (Pyruvate Kinase M2) deactivates the AKT and/or mTOR signalling pathway, thereby decreasing the SREBP-1c expression which inhibits the generation of fatty acid by inhibiting the FASN gene transcription, resulting in the inhibited tumor cell growth

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Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology