CT-388 was generally well tolerated, with most gastrointestinal adverse events described as mild to moderate and consistent with the incretin class
Though, all dosages of the oral version of semaglutide decreased average HbA1c (from -0,7 percent to -1,9%) significantly more than placebo (-0,3%) by the end of the trial
Emerging evidence also suggests potential cardiovascular benefits, with some injectable GLP-1 receptor agonists demonstrating reduced risk of major adverse cardiovascular events in people with established cardiovascular disease
Layton C, Safa R, Osborne N
Mazdutide Developed by Innovent Biologics in partnership with Eli Lilly, mazdutide is another GLP-1/glucagon dual agonist currently in advanced clinical trials, primarily in China
Costs and Incentives: Not all stakeholders have equal incentive