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Current clinical data, including a high-quality meta-analysis, strongly suggest that targeted probiotics therapy can modulate markers of bone turnover (BTMs): BTM markers are decreased for resorption, such as CTX-I and TRAP-5b, while they remain unchanged for formation, such as P1NP or osteocalcin, in a meta-analysis of 2026 RCTs (n = 1432) (295)

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