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doi: 10.3390/md18050239

However, robust clinical evidence in humans remains limited, with most published data coming from laboratory and animal studies rather than large randomized trials

This new study underscores one important reality: patients are highly motivated to lose weight and may tolerate side effects if they believe the drug is working

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1 Introduction Diabetic kidney disease (DKD) is a major microvascular complication of diabetes and the foremost contributor to end-stage renal disease (ESRD), affecting nearly half of type 2 diabetes mellitus (T2DM) patients ( Traditional therapy for DKD is mainly aimed at controlling blood glucose, levels blood pressure, and blood lipids, supplemented by anti-inflammatory and anti-fibrotic therapies as well as lifestyle interventions ( As one of the most essential symbiotic ecosystems in the human body, the gut microbiota plays a pivotal role in energy metabolism, immune regulation, and the maintenance of epithelial barrier homeostasis ( 2 Materials and methods 2.1 Animals and grouping design All mice for the experiment were obtained from Nanjing Universitys Model Animal Research Center, including seven-week-old male diabetic C57BL/KSJ db/db mice and littermate control db/m mice

This was changed to a single 7.2mg pen (one pen per dose) from 1 June 2026