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Alternatively, continuous daily dosing for 12 weeks followed by a 4-week break is another common approach

Preliminary results for the four cobalamins in this Perspective are very promising, and provide a more in-depth understanding of recent experimental results

Wyatt HA, Dhawan A, Cheeseman P, Mieli-Vergani G, Price JF

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Finally, we discuss translational gaps including scalability, regulatory hurdles, and patient-specific variability that must be addressed for successful clinical implementation

The major conformational dynamics of AMY 1 R-Gs and AMY 2 R-Gs bound to individual peptide agonists were primarily related to motions of the combined RAMP:CTR ECD relative to the TM core, and this was also true for previously determined AMY 3 R-Gs complexes with rAmy (Fig